Endometrial cancer is on the rise, and so are the disparities in survival rates. While white women diagnosed with the disease have an 84% five-year survival rate, Black women face a significantly lower rate of just 63%. This alarming gap has prompted a major federal investment aimed at understanding and closing the divide.
Researchers at the University of North Carolina have been awarded an $11.2 million grant from the National Cancer Institute to investigate why Black women are more likely to die from endometrial cancer. The team, led by Dr. Victoria Bae-Jump and Dr. Hazel Nichols, will explore both biological and social factors that may drive more aggressive disease and poorer outcomes.
“Chronic stress, changes in the immune system, metabolism, gut bacteria and how cells age” are among the contributors being studied, said Nichols. The research will build on UNC’s Carolina Endometrial Cancer Study, which includes data from over 1,700 patients across North Carolina.
The project will examine how disparities intersect with epigenetic aging, the microbiome, and obesity-related metabolic changes. Researchers aim to develop biomarkers to identify high-risk patients and create tailored interventions, including drugs and lifestyle-based treatments.
Community engagement is central to the effort. The team will work with local organizations to listen to patients, promote research participation, and share findings widely. “We’re working toward a future where we can offer every woman with endometrial cancer access to better, more personalized care,” said Bae-Jump.
See: “Researchers awarded $11.2M grant to close endometrial cancer survival gap” (October 9, 2025)
